Genetically-altered creatures known as Enterrans take over Earth and rename it in their own image called Enterra. Now three Enterrans have to protect the last human in order to find the hidden sanctuary called Shinzo and restore the human race.
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The story follows the human girl Yakumo, who awakens from cryogenic sleep in a devastated world destroyed by genetically engineered lifeforms, Enterrans. With the help of a few friendly Enterrans, she goes on a journey to find more human survivors and bring peace between the two factions.
After restoring the world to order, one threat remains for Yakumo and her friends. The cause of the war itself, hidden deep inside a meteorite that crashed at the start of the war, a cause that's about to resurface.